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The Role of Biotin and Hair Loss | zenagen

The role of Biotin (B7) and Hair Loss.

Many people concerned with hair loss have heard of supplement or vitamin called biotin, and often ask if it is beneficial to hair loss and growing thicker hair.

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Here is a brief synopsis of biotin as it pertains to hair.

The supplement biotin is actually vitamin B7, which is a water-soluble vitamin. The vitamin is referred to as the hair vitamin and is sometimes claimed to be useful for stimulating hair growth or for treating hair loss. However, there is little scientific evidence to support such claims.

Biotin and Hair:

A biotin deficiency can cause hair loss (known medically as alopecia) and that treating a deficiency can help restore normal hair growth. However, biotin deficiencies are quite rare. The body needs only a tiny amount, and many foods contain it. Also, the intestinal flora (the microorganisms that live in the digestive tract) produce biotin that the body can use, and the vitamin is “recycled” in the body.
zenagenThere is no scientific evidence to suggest that biotin can stimulate hair growth or treat hair loss in people with normal levels.

Is My Hair Loss Caused by a Biotin Deficiency?

If you have a deficiency, biotin could help to stop hair loss and stimulate hair growth. 

However, most cases of hair loss are not caused by a deficiency, and it is unlikely that hair loss would be the only symptom. Other signs are often experienced as well, such as:
  • Red, scaly facial rash
  • Depression
  • Lethargy
  • Hallucinations
  • Unusual sensations (such as pricking or burning) of the hands or feet.
Most people may be able to meet their biotin requirement through food. However, higher intakes may be recommended in certain situations, such as:
  • Biotinidase deficiency (a genetic disorder)
  • Chronic use of certain seizure medications or antibiotics (see Biotin Drug Interactions)
  • Consumption of large quantities of raw egg whites, which contain a substance that causes biotin depletion
  • Kidney dialysis or IV feedings (known as total parenteral nutrition or TPN) that do not contain biotin.

In short the amount of biotin related hair loss is very small in the normal population. Almost everyone gets enough biotin through normal diet.


The Role of Selenium in Hair and Skin | zenagen

Selenium Role in Healthy Skin and Hair

zenagenStudy shows selenium and selenoproteins play beneficial role in the health of hair and keratinocytes.

The trace mineral Selenium is essential to the body and good health, with a small amount of it going a long way. Selenium is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes.

The antioxidant properties of selenoproteins help prevent cellular oxidative damage from free radicals. Free radicals are natural by-products of oxygen metabolism that may contribute to the development of chronic diseases such as cancer and heart disease. Other Selenoproteins have been shown to help regulate thyroid function and play a role in the immune system.

Recently a study was published by the National Institute of Health (NIH) and other organizations regarding Selenium and Selenoproteins. The result: They concluded that selenoproteins are essential for proper keratinocyte function and skin development.

The study focused on selenium deficiency and showed a correlation to higher abnormalities in skin and hair.

Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin. Furthermore, skin and hair abnormalities in humans and rodents may be caused by selenium deficiency, which are overcome by dietary selenium supplementation.

Most important biological functions of selenium are attributed to selenoproteins, proteins containing selenium in the form of the amino acid, selenocysteine (Sec). Sec insertion into proteins depends on Sec tRNA; thus, knocking out the Sec tRNA gene (Trsp) ablates selenoprotein expression. Generated mice were used with targeted removal of selenoproteins in keratin 14 (K14) expressing cells and their differentiated descendents.

The knockout progeny had a runt phenotype, developed skin abnormalities and experienced premature death. Lack of selenoproteins in epidermal cells led to the development of hyperplastic epidermis and aberrant hair follicle morphogenesis, accompanied by progressive alopecia after birth.

Further analyses revealed that selenoproteins are essential antioxidants in skin and unveiled their role in keratinocyte growth and viability. This study links severe selenoprotein deficiency to abnormalities in skin and hair and provides genetic evidence for the role of these proteins in keratinocyte function and cutaneous development.

More studies are likely to investigate further into the benefits of selenium and hair and skin.

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